Brock Purdy injury update: 49ers make final decision on QB's status vs. Rams

by: Daniel Hager 52 minutes ago DanielHagerOn3

The 3-1 San Francisco 49ers will be extremely shorthanded on offense heading into their Week 5 matchup against the also 3-1 Los Angeles Rams Thursday night.

Quarterback Brock Purdy (toe) and wide receivers Ricky Pearsall (knee) and Jauan Jennings (ankle, ribs) have all been ruled out of San Francisco’s TNF clash against the Rams, per ESPN ‘s Adam Schefter .

Brock Purdy (toe), Ricky Pearsall (knee), Jauan Jennings (ankle, ribs) are out Thursday night vs. the Rams.

— Adam Schefter (@AdamSchefter) October 1, 2025

This marks Purdy’s third missed game of the season, while Jennings will miss his second game and Pearsall will miss his first game. The trio have played together in just two of San Francisco’s four games this season (1-1). Backup quarterback Mac Jones will make his third start of the season for the 49ers. In his previous two starts, he’d led the Niners to wins over the Arizona Cardinals and New Orleans Saints.

The former Pro Bowler boasts 563 yards passing, four touchdowns and one interceptions in two starts. Purdy, in two starts, has put up extremely similar numbers. He has Jones beat with 586 yards passing, but has also tossed four touchdowns along with four interceptions. Although San Francisco has dealt with the injury bug all across its offense, it is averaging 368 yards per game (5th most in NFL).

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