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NFL Fantasy 2025 Start 'Em, Sit 'Em: Defenses for Week 10

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You have lineup questions, we have lineup answers — at least we hope so. Start ‘Em, Sit ‘Em is here to help fantasy managers make difficult roster decisions. And you know what is a good move? Starting Justin Jefferson. But that’s too obvious, so you won’t see such simple analysis here. Instead, we’re exploring more debatable situations. And if you can’t find a player you are looking for, please check out the latest NFL Fantasy lineup rankings.

NOTE: Unless otherwise indicated, all stats come from NFL Pro, Next Gen Stats or NFL Research.

Start ‘Em

VS.

Denver’s defense is in play most weeks, but the unit is an absolute MUST-START in this matchup. The Broncos comfortably lead the league in sacks. This week, they face the Raiders, who have taken sacks at a top-10 rate. The Raiders have given the ball away at the third-highest rate in the NFL, too. In total, Vegas has allowed the third-most fantasy PPG to opposing defenses.

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