NFL Fantasy 2025 Start 'Em, Sit 'Em: Defenses for Week 15

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You have lineup questions, we have lineup answers — at least we hope so. Start ‘Em, Sit ‘Em is here to help fantasy managers make difficult roster decisions. And you know what is a good move? Starting Jahmyr Gibbs. But that’s too obvious, so you won’t see such simple analysis here. Instead, we’re exploring more debatable situations. And if you can’t find a player you are looking for, please check out the latest NFL Fantasy lineup rankings.

NOTE: Unless otherwise indicated, all stats come from NFL Pro, Next Gen Stats or NFL Research.

Start ‘Em

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The banged-up 49ers have typically have been a defense to stream against, but this week they face a Titans team that has allowed the second-most fantasy PPG to opposing defenses. Tennessee has taken sacks at the fourth-highest rate and has had issues with giveaways, allowing some week-altering performances to defenses. The 49ers are coming off their best fantasy performance against the Browns, which proved they can take advantage of a good matchup.

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