NFL Fantasy 2025 Start 'Em, Sit 'Em: Running backs for Week 2

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You have lineup questions, we have lineup answers — at least we hope so. Start ‘Em, Sit ‘Em is here to help fantasy managers make difficult roster decisions. And you know what is a good move? Starting Ja’Marr Chase. But that’s too obvious, so you won’t see such simple analysis here. Instead, we’re exploring more debatable situations. And if you can’t find a player you are looking for, please check out the latest NFL Fantasy lineup rankings.

NOTE: Unless otherwise indicated, all stats come from NFL Pro, Next Gen Stats or NFL Research.

Start ‘Em

VS.

You all watched Sunday Night Football and saw what Derrick Henry did to the Bills. Sure, not everyone is going to pile up more than 180 yards and multiple touchdowns against Buffalo, but the Bills have struggled against running backs for a while now. Last year, they allowed the fifth-most fantasy points per game to RBs, including the most receiving yards and second-most receiving touchdowns. Hall has a history of success against Buffalo, too. He got the Bills for 169 total yards in one game last season and has topped 140 yards in half of his career games against them. He’s topped double-digit fantasy points in three of four matchups vs. these division rivals, averaging 15.5 fantasy PPG. Plus, Justin Fields clearly is going to help the run game. Start Hall.

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