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NFL Week 1 picks for all 16 games: Eagles over Cowboys; Chiefs beat Chargers in Brazil

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2025-09-04

by Tom Blair , Brooke Cersosimo , Gennaro Filice & Dan Parr

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NFL.com editors Ali Bhanpuri, Tom Blair, Brooke Cersosimo, Gennaro Filice and Dan Parr will predict the winner of every game in the 2025 NFL season, using the unbeatable combo of football analysis and excessive punctuation. Check out their Week 1 NFL picks below.

The lines provided by DraftKings are locked as of noon ET on Thursday, Sept. 4.

THURSDAY, SEPT. 4

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