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The 49ers will play a Thursday night prime-time game without a handful of stars.
Quarterback Brock Purdy (toe) and receivers Jauan Jennings (ankle/rib) and Ricky Pearsall (knee) will not play in San Francisco’s game in Los Angeles against the Rams. Mac Jones will start in place for Purdy.
Receiver Jordan Watkins (calf) and defensive end Robert Beal Jr. (ankle) will also miss the game.
Purdy missed Weeks 2-3 with the toe injury suffered in the 49ers’ comeback win over the Seahawks in Week 1 and was able to return for San Francisco’s close loss to Jacksonville in Week 4. After the game, Purdy reported discomfort in the toe, prompting the 49ers to take “every precaution to make sure Brock’s all right,” general manager John Lynch said during a Tuesday radio interview.
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With a short turnaround to the Thursday night game, those precautions weren’t enough to improve Purdy’s health. His absence will call Jones back into action to replace him in a game that will be increasingly difficult without Pearsall, Watkins and Jennings.