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PFT’s Week 5 2025 NFL picks: Florio vs. Simms

Mike Florio ,

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The lead is down to six. This week, things could change dramatically.

We disagree on six of 14 games.

Last week, Simms won the slate with 12-3-1 straight up. I went 11-4-1. Against the spread, I was 12-4 to his 11-5.

For the season, I’m 47-16-1 straight up. He’s 41-23-1. Against the spread, I’m 38-26. He’s 30-34.

All Week 5 picks appear below.

If you bet, with or without our picks as guidance, be careful. Treat it as entertainment. Don’t chase your losses. And only wager with money you can afford to lose. Over time, you will. (Deep down, you know it.)

Despite the identical 3-1 records, one team is firmly in the Super Bowl window. One is not.

Florio’s pick: Rams 27, 49ers 17.

Simms’s pick: Rams 27, 49ers 17.

Vikings (-4.5) vs. Browns at London

The extra acclimation time for the Vikings, who played in Ireland last week, combined with a rookie quarterback facing the Brian Flores defense is the difference, as I see it. Simms thinks the Vikings’ offensive line will be overwhelmed by Cleveland’s defense.

Florio’s pick: Vikings 20, Browns 10.

Simms’s pick: Browns 20, Vikings 17.

It’s no longer about desperation for the Ravens. It’s about simple, basic pride.

Florio’s pick: Ravens 19, Texans 13.

Simms’s pick: Texans 27, Ravens 13.

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